Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

Antiretroviral therapy (ART) suppresses HIV replication in most individuals but cannot eradicate latently infected cells established before ART was initiated. Thus, infection rebounds when treatment is interrupted by reactivation of virus production from this reservoir. Currently, one or a few laten...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Rothenberger, Meghan K., Keele, Brandon F., Wietgrefe, Stephen W., Fletcher, Courtney V., Beilman, Gregory J., Chipman, Jeffrey G., Khoruts, Alexander, Estes, Jacob D., Anderson, Jodi, Callisto, Samuel P., Schmidt, Thomas E., Thorkelson, Ann, Reilly, Cavan, Perkey, Katherine, Reimann, Thomas G., Utay, Netanya S., Nganou Makamdop, Krystelle, Stevenson, Mario, Douek, Daniel C., Haase, Ashley T., Schacker, Timothy W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364237/
https://ncbi.nlm.nih.gov/pubmed/25713386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414926112
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