Impact of Integrase Inhibition Compared With Nonnucleoside Inhibition on HIV Reservoirs in Lymphoid Tissues

BACKGROUND: HIV is produced in lymphoid tissues (LT) and stored on the follicular dendritic cell network in LT. When antiretroviral therapy is started, plasma viremia decays in 2 phases; the first within days of starting therapy and the second over weeks. Raltegravir (RAL), an integrase inhibitor, h...

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Bibliographic Details
Published in:J Acquir Immune Defic Syndr
Main Authors: Rothenberger, Meghan, Nganou-Makamdop, Krystelle, Kityo, Cissy, Ssali, Francis, Chipman, Jeffrey G., Beilman, Gregory J., Hoskuldsson, Torfi, Anderson, Jodi, Jasurda, Jake, Schmidt, Thomas E., Calisto, Samuel P., Pearson, Hope, Reimann, Thomas, David, Caitlin, Perkey, Katherine, Southern, Peter, Wietgrefe, Steve, Helgeson, Erika, Reilly, Cavan, Haase, Ashley T., Douek, Daniel C, Fletcher, Courtney V., Schacker, Timothy W.
Format: Artigo
Language:Inglês
Published: JAIDS Journal of Acquired Immune Deficiency Syndromes 2019
Subjects:
Translational Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582649/
https://ncbi.nlm.nih.gov/pubmed/31192893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000002026
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