Impact of Integrase Inhibition Compared With Nonnucleoside Inhibition on HIV Reservoirs in Lymphoid Tissues

BACKGROUND: HIV is produced in lymphoid tissues (LT) and stored on the follicular dendritic cell network in LT. When antiretroviral therapy is started, plasma viremia decays in 2 phases; the first within days of starting therapy and the second over weeks. Raltegravir (RAL), an integrase inhibitor, h...

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Detalhes bibliográficos
Publicado no:J Acquir Immune Defic Syndr
Main Authors: Rothenberger, Meghan, Nganou-Makamdop, Krystelle, Kityo, Cissy, Ssali, Francis, Chipman, Jeffrey G., Beilman, Gregory J., Hoskuldsson, Torfi, Anderson, Jodi, Jasurda, Jake, Schmidt, Thomas E., Calisto, Samuel P., Pearson, Hope, Reimann, Thomas, David, Caitlin, Perkey, Katherine, Southern, Peter, Wietgrefe, Steve, Helgeson, Erika, Reilly, Cavan, Haase, Ashley T., Douek, Daniel C, Fletcher, Courtney V., Schacker, Timothy W.
Formato: Artigo
Idioma:Inglês
Publicado em: JAIDS Journal of Acquired Immune Deficiency Syndromes 2019
Assuntos:
Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582649/
https://ncbi.nlm.nih.gov/pubmed/31192893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000002026
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