Binding of Complement Factor H to PorB3 and NspA Enhances Resistance of Neisseria meningitidis to Anti-Factor H Binding Protein Bactericidal Activity

Among 25 serogroup B Neisseria meningitidis clinical isolates, we identified four (16%) with high factor H binding protein (FHbp) expression that were resistant to complement-mediated bactericidal activity of sera from mice immunized with recombinant FHbp vaccines. Two of the four isolates had evide...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Giuntini, Serena, Pajon, Rolando, Ram, Sanjay, Granoff, Dan M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363443/
https://ncbi.nlm.nih.gov/pubmed/25644002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02984-14
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