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Binding of Complement Factor H (fH) to Neisseria meningitidis Is Specific for Human fH and Inhibits Complement Activation by Rat and Rabbit Sera

Complement factor H (fH), a molecule that downregulates complement activation, binds to Neisseria meningitidis and increases resistance to serum bactericidal activity. We investigated the species specificity of fH binding and the effect of human fH on downregulating rat (relevant for animal models)...

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Sonraí Bibleagrafaíochta
Main Authors: Granoff, Dan M., Welsch, Jo Anne, Ram, Sanjay
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632036/
https://ncbi.nlm.nih.gov/pubmed/19047406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01191-08
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