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Homocysteine Exacerbates β-Amyloid Pathology, Tau Pathology, and Cognitive Deficit in a Mouse Model of Alzheimer Disease with Plaques and Tangles
OBJECTIVE: High level of homocysteine (Hcy) is a recognized risk factor for developing Alzheimer disease (AD). However, the mechanisms involved are unknown. Previously, it was shown that high Hcy increases brain b-amyloid (Ab) levels in amyloid precursor protein transgenic mice, but no data are avai...
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| Published in: | Ann Neurol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4362695/ https://ncbi.nlm.nih.gov/pubmed/24644038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24145 |
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