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Zileuton Improves Memory Deficits, Amyloid and Tau Pathology in a Mouse Model of Alzheimer’s Disease with Plaques and Tangles

The 5-lipoxygenase (5LO) enzyme is widely distributed within the central nervous system. Previous works showed that this protein is up-regulated in Alzheimer’s disease (AD), and plays an active role in the development of brain amyloidosis in the APP transgenic mice. In the present paper, we studied...

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Autori principali: Chu, Jin, Li, Jin-Guo, Praticò, Domenico
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737232/
https://ncbi.nlm.nih.gov/pubmed/23951061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070991
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