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Elevated levels of brain homocysteine directly modulates the pathological phenotype of a mouse model of tauopathy

High circulating level of homocysteine (Hcy), also known as hyper-homocysteinemia, is a risk factor for Alzheimer’s disease (AD). Previous studies showed that elevated Hcy promotes brain amyloidosis and behavioral deficits in mouse models of AD. However, whether it also directly modulates the develo...

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Detalles Bibliográficos
Publicado en:Mol Psychiatry
Main Authors: Di Meco, Antonio, Li, Jian-Guo, Barrero, Carlos, Merali, Salim, Praticò, Domenico
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215750/
https://ncbi.nlm.nih.gov/pubmed/29728702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0062-0
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