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Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer’s phenotype

Environmental and genetic risk factors are implicated in the pathogenesis of Alzheimer’s disease (AD). However, how they interact and influence its pathogenesis remains to be investigated. High level of homocysteine (Hcy) is an AD risk factor and associates with an up-regulation of the ALOX5 gene. I...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Li, Jian-Guo, Barrero, Carlos, Merali, Salim, Praticò, Domenico
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382538/
https://ncbi.nlm.nih.gov/pubmed/28383037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46002
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