The BRAF kinase domain promotes the development of gliomas in vivo

In-frame BRAF fusions have been observed in over 80% of sporadic pilocytic astrocytomas. In each fusion, the N-terminal autoinhibitory domain of BRAF is lost, which results in constitutive activation via the retained C-terminal kinase domain (BRAF-KD). We set out to determine if the BRAF-KD is suffi...

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Udgivet i:Genes Cancer
Main Authors: Shin, Clifford H., Grossmann, Allie H., Holmen, Sheri L., Robinson, James P.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362480/
https://ncbi.nlm.nih.gov/pubmed/25821557
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