NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2

The Ras oncoprotein is a key driver of cancer. However, Ras also provokes senescence, which serves as a major barrier to Ras-driven transformation. Ras senescence pathways remain poorly characterized. NORE1A is a novel Ras effector that serves as a tumor suppressor. It is frequently inactivated in t...

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Bibliografiska uppgifter
I publikationen:J Cell Biol
Huvudupphovsmän: Donninger, Howard, Calvisi, Diego F., Barnoud, Thibaut, Clark, Jennifer, Schmidt, M. Lee, Vos, Michele D., Clark, Geoffrey J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2015
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362463/
https://ncbi.nlm.nih.gov/pubmed/25778922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201408087
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