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NORE1A is a double barreled Ras senescence effector that activates p53 and Rb
Although Ras is a potent oncogene in human tumors it has the paradoxical ability to promote Oncogene Induced Senescence (OIS). This appears to serve as a major barrier to Ras driven transformation in vivo. The signaling pathways used by Ras to promote senescence remain relatively poorly understood,...
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| 出版年: | Cell Cycle |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5004699/ https://ncbi.nlm.nih.gov/pubmed/26919075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1152431 |
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