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NORE1A is a double barreled Ras senescence effector that activates p53 and Rb

Although Ras is a potent oncogene in human tumors it has the paradoxical ability to promote Oncogene Induced Senescence (OIS). This appears to serve as a major barrier to Ras driven transformation in vivo. The signaling pathways used by Ras to promote senescence remain relatively poorly understood,...

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Dades bibliogràfiques
Publicat a:Cell Cycle
Autors principals: Donninger, Howard, Barnoud, Thibaut, Clark, Geoffrey J.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004699/
https://ncbi.nlm.nih.gov/pubmed/26919075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1152431
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