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FOXP3(+) regulatory T cell development and function require histone/protein deacetylase 3

Treg dysfunction is associated with a variety of inflammatory diseases. Treg populations are defined by expression of the oligomeric transcription factor FOXP3 and inability to produce IL-2, a cytokine required for T cell maintenance and survival. FOXP3 activity is regulated post-translationally by...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wang, Liqing, Liu, Yujie, Han, Rongxiang, Beier, Ulf H., Bhatti, Tricia R., Akimova, Tatiana, Greene, Mark I., Hiebert, Scott W., Hancock, Wayne W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362235/
https://ncbi.nlm.nih.gov/pubmed/25642770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI77088
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