Quantification of Histone H3 Lys27 Trimethylation (H3K27me3) by High-Throughput Microscopy Enables Cellular Large-Scale Screening for Small-Molecule EZH2 Inhibitors

EZH2 inhibition can decrease global histone H3 lysine 27 trimethylation (H3K27me3) and thereby reactivates silenced tumor suppressor genes. Inhibition of EZH2 is regarded as an option for therapeutic cancer intervention. To identify novel small-molecule (SMOL) inhibitors of EZH2 in drug discovery, t...

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Bibliographic Details
Published in:J Biomol Screen
Main Authors: Luense, Svenja, Denner, Philip, Fernández-Montalván, Amaury, Hartung, Ingo, Husemann, Manfred, Stresemann, Carlo, Prechtl, Stefan
Format: Artigo
Language:Inglês
Published: SAGE Publications 2015
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361481/
https://ncbi.nlm.nih.gov/pubmed/25409661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057114559668
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