Activin/Smad2-induced Histone H3 Lys-27 Trimethylation (H3K27me3) Reduction Is Crucial to Initiate Mesendoderm Differentiation of Human Embryonic Stem Cells

Differentiation of human embryonic stem cells into mesendoderm (ME) is directed by extrinsic signals and intrinsic epigenetic modifications. However, the dynamics of these epigenetic modifications and the mechanisms by which extrinsic signals regulate the epigenetic modifications during the initiati...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wang, Lu, Xu, Xuanhao, Cao, Yaqiang, Li, Zhongwei, Cheng, Hao, Zhu, Gaoyang, Duan, Fuyu, Na, Jie, Han, Jing-Dong J., Chen, Ye-Guang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270477/
https://ncbi.nlm.nih.gov/pubmed/27965357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.766949
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