Activin/Smad2-induced Histone H3 Lys-27 Trimethylation (H3K27me3) Reduction Is Crucial to Initiate Mesendoderm Differentiation of Human Embryonic Stem Cells

Differentiation of human embryonic stem cells into mesendoderm (ME) is directed by extrinsic signals and intrinsic epigenetic modifications. However, the dynamics of these epigenetic modifications and the mechanisms by which extrinsic signals regulate the epigenetic modifications during the initiati...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Wang, Lu, Xu, Xuanhao, Cao, Yaqiang, Li, Zhongwei, Cheng, Hao, Zhu, Gaoyang, Duan, Fuyu, Na, Jie, Han, Jing-Dong J., Chen, Ye-Guang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Developmental Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270477/
https://ncbi.nlm.nih.gov/pubmed/27965357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.766949
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