Activin/Smad2 and Wnt/β-catenin up-regulate HAS2 and ALDH3A2 to facilitate mesendoderm differentiation of human embryonic stem cells

Activin and Wnt signaling are necessary and sufficient for mesendoderm (ME) differentiation of human embryonic stem cells (ESCs). In this study, we report that during ME differentiation induced by Activin and Wnt, Activin/Smad2 induces a decrease of the repressive histone modification of H3K27me3 by...

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Vydáno v:J Biol Chem
Hlavní autoři: Xu, Xuanhao, Wang, Lu, Liu, Bofeng, Xie, Wei, Chen, Ye-Guang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290156/
https://ncbi.nlm.nih.gov/pubmed/30282636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003688
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