Evaluation of Histone 3 Lysine 27 Trimethylation (H3K27me3) and Enhancer of Zest 2 (EZH2) in Pediatric Glial and Glioneuronal Tumors Shows Decreased H3K27me3 in H3F3A K27M Mutant Glioblastomas

H3F3A mutations are seen in ∼30% of pediatric glioblastoma (GBMs) and involve either the lysine residue at position 27 (K27M) or glycine at position 34 (G34R/V). Sixteen genes encode histone H3, each variant differing in only a few amino acids. Therefore, how mutations in a single H3 gene contribute...

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Autors principals: Venneti, Sriram, Garimella, Mihir T., Sullivan, Lisa M., Martinez, Daniel, Huse, Jason T., Heguy, Adriana, Santi, Mariarita, Thompson, Craig B., Judkins, Alexander R.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2013
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701028/
https://ncbi.nlm.nih.gov/pubmed/23414300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12042
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