Histone Deacetylase Inhibitors Prevent Apoptosis following Lethal Hemorrhagic Shock in Rodent Kidney Cells

BACKGROUND: We have previously demonstrated that treatment with histone deacetylase inhibitors (HDACI), such as valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA), can improve survival after hemorrhagic shock in animal models. Hemorrhage results in hypoacetylation of proteins which is re...

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Publicado no:Resuscitation
Main Authors: Zacharias, Nikolaos, Sailhamer, Elizabeth A., Li, Yongqing, Liu, Baoling, Butt, Muhammad U., Shuja, Fahad, Velmahos, George C., de Moya, Marc, Alam, Hasan B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361066/
https://ncbi.nlm.nih.gov/pubmed/21036453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resuscitation.2010.09.469
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