HISTONE DEACETYLASE INHIBITOR TREATMENT ATTENUATES MAP KINASE PATHWAY ACTIVATION AND PULMONARY INFLAMMATION FOLLOWING HEMORRHAGIC SHOCK IN A RODENT MODEL

BACKGROUND: Hemorrhagic shock activates cellular stress signals and can lead to systemic inflammatory response, organ injury, and death. We have previously shown that treatment with histone deacetylase inhibitors (HDACIs) significantly improves survival in lethal models (60% blood loss) of hemorrhag...

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Bibliografiske detaljer
Main Authors: Kochanek, Ashley R., Fukudome, Eugene Y., Li, Yongqing, Smith, Eleanor J., Liu, Baoling, Velmahos, George C., deMoya, Marc, King, David, Alam, Hasan B.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210894/
https://ncbi.nlm.nih.gov/pubmed/21816439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2011.06.007
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