Histone Deacetylase Inhibitor SAHA Attenuates TLR4 Signaling in LPS-Stimulated Mouse Macrophages

OBJECTIVE: We have previously demonstrated that pre- and post-treatment of animals with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACI), can improve survival in a mouse model of lipopolysaccharides (LPS)-induced severe shock. This study was to assess whether SAHA affe...

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Detalhes bibliográficos
Main Authors: Chong, Wei, Li, Yongqing, Liu, Baoling, Zhao, Ting, Fukudome, Eugene Y., Liu, Zhengcai, Smith, William M., Velmahos, George C., deMoya, Marc, Alam, Hasan B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496062/
https://ncbi.nlm.nih.gov/pubmed/22868051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2012.07.023
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