ANTI-INFLAMMATORY PROPERTIES OF HISTONE DEACETYLASE INHIBITORS: A MECHANISTIC STUDY

BACKGROUND: We have demonstrated that post-shock administration of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACI), can significantly improve early survival in a highly lethal model of hemorrhagic shock. As the primary insult in hemorrhagic shock is cellular hypoxia,...

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Detalhes bibliográficos
Main Authors: Chong, Wei, Li, Yongqing, Liu, Baoling, Liu, Zhengcai, Zhao, Ting, Wonsey, Diane R., Chen, Changmin, Velmahos, George C., deMoya, Marc A., King, David R., Kung, Andrew L., Alam, Hasan B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782098/
https://ncbi.nlm.nih.gov/pubmed/22327976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0b013e318243d8b2
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