Histone Deacetylase Inhibitors: Isoform Selectivity Improves Survival in a Hemorrhagic Shock Model

BACKGROUND: Hemorrhage is a leading preventable cause of death. Non-selective histone deacetylase inhibitors (HDACIs), such as valproic acid (VPA), have been shown to improve outcomes in hemorrhagic shock (HS). HDACs can be divided into 4 functional classes (I, IIa/IIb, III & IV). Classes I, IIa...

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Bibliografiske detaljer
Udgivet i:J Trauma Acute Care Surg
Main Authors: Chang, Panpan, Weykamp, Michael, Dennahy, Isabel S., Williams, Aaron M., Bhatti, Umar F., Liu, Baoling, Nikolian, Vahagn C., Li, Yongqing, Alam, Hasan B.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318805/
https://ncbi.nlm.nih.gov/pubmed/29401190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000001824
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