Valproic Acid Attenuates Neural Apoptosis, Inflammation, and Degeneration 30 Days after Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma in a Swine Model

INTRODUCTION: A single-dose (150mg/kg) of valproic acid (VPA) has been shown to decrease brain lesion size and improve neurologic recovery in pre-clinical models of traumatic brain injury (TBI). However, the long-term impact of single-dose VPA following TBI has not been well evaluated. METHODS: York...

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Pubblicato in:J Am Coll Surg
Autori principali: Chang, Panpan, Williams, Aaron M., Bhatti, Umar F., Biesterveld, Ben E., Liu, Baoling, Nikolian, Vahagn C., Dennahy, Isabel, Lee, Jessica, Li, Yongqing, Alam, Hasan B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589830/
https://ncbi.nlm.nih.gov/pubmed/30639301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jamcollsurg.2018.12.026
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