Validation of intraosseous delivery of valproic acid in a swine model of polytrauma

BACKGROUND: Intraosseous (IO) drug delivery may be necessary in emergency situations when intravenous access is unattainable. Valproic acid (VPA) is a histone deacetylase inhibitor that has previously been shown to improve survival in preclinical models of lethal polytrauma. In this study, we sought...

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Опубликовано в: :Trauma Surg Acute Care Open
Главные авторы: Biesterveld, Ben E, O’Connell, Rachel, Kemp, Michael T, Wakam, Glenn K, Williams, Aaron M, Pai, Manjunath P, Alam, Hasan B
Формат: Artigo
Язык:Inglês
Опубликовано: BMJ Publishing Group 2021
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978107/
https://ncbi.nlm.nih.gov/pubmed/33791436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/tsaco-2021-000683
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