Inhibition of Histone Deacetylase 6 Restores Intestinal Tight Junction in Hemorrhagic Shock

BACKGROUND: We recently discovered that Tubastatin-A, histone deacetylase (HDAC6) inhibitor, can improve survival in a rodent model of hemorrhagic shock (HS), but mechanisms remain poorly defined. In this study we investigated whether Tubastatin-A could protect intestinal tight junction (TJ) in HS....

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Pubblicato in:J Trauma Acute Care Surg
Autori principali: Chang, Zhigang, Li, Yongqing, He, Wei, Liu, Baoling, Duan, Xiuzhen, Halaweish, Ihab, Bambakidis, Ted, Pan, Baihong, Liang, Yingjian, Nikolian, Vahagn C., Georgoff, Patrick, Alam, Hasan B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001880/
https://ncbi.nlm.nih.gov/pubmed/27257709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000001137
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