Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload

Left ventricular (LV) volume overload (VO) results in cardiomyocyte oxidative stress and mitochondrial dysfunction. Because mitochondria are both a source and target of ROS, we hypothesized that the mitochondrially targeted antioxidant mitoubiquinone (MitoQ) will improve cardiomyocyte damage and LV...

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Bibliographic Details
Published in:Am J Physiol Heart Circ Physiol
Main Authors: Yancey, Danielle M., Guichard, Jason L., Ahmed, Mustafa I., Zhou, Lufang, Murphy, Michael P., Johnson, Michelle S., Benavides, Gloria A., Collawn, James, Darley-Usmar, Victor, Dell'Italia, Louis J.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
Subjects:
Integrative Cardiovascular Physiology and Pathophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360051/
https://ncbi.nlm.nih.gov/pubmed/25599572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00638.2014
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