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Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells

Short-term starvation or fasting can augment cancer treatment efficacy and can be effective in delaying cancer progression in the absence of chemotherapy, but the underlying molecular mechanisms of action remain elusive. Here we describe the role of REV1, a specialized DNA polymerase involved in DNA...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Shim, Hong Seok, Wei, Min, Brandhorst, Sebastian, Longo, Valter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359966/
https://ncbi.nlm.nih.gov/pubmed/25614517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2249
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