Tyrosinase Overexpression Promotes ATM-Dependent p53 Phosphorylation by Quercetin and Sensitizes Melanoma Cells to Dacarbazine

Dacarbazine (DTIC) has been used for the treatment of melanoma for decades. However, monotherapy with this chemotherapeutic agent results only in moderate response rates. To improve tumor response to DTIC current clinical trials in melanoma focus on combining a novel targeted agent with chemotherapy...

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Bibliografiset tiedot
Julkaisussa:Cell Oncol
Päätekijät: Thangasamy, Thilakavathy, Sittadjody, Sivanandane, H. Limesand, Kirsten, Burd, Randy
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: IOS Press 2008
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618806/
https://ncbi.nlm.nih.gov/pubmed/18791269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/CLO-2008-0441
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