Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polζ-dependent mechanism

Oncogenes contribute to tumorigenesis by promoting growth and inhibiting apoptosis. Here we examine the function of Sch9, the Saccharomyces cerevisiae homologue of the mammalian Akt and S6 kinase, in DNA damage and genomic instability during aging in nondividing cells. Attenuation of age-dependent i...

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Detalhes bibliográficos
Main Authors: Madia, Federica, Wei, Min, Yuan, Valerie, Hu, Jia, Gattazzo, Cristina, Pham, Phuong, Goodman, Myron F., Longo, Valter D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733759/
https://ncbi.nlm.nih.gov/pubmed/19687253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200906011
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