Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polζ-dependent mechanism

Oncogenes contribute to tumorigenesis by promoting growth and inhibiting apoptosis. Here we examine the function of Sch9, the Saccharomyces cerevisiae homologue of the mammalian Akt and S6 kinase, in DNA damage and genomic instability during aging in nondividing cells. Attenuation of age-dependent i...

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Bibliografski detalji
Glavni autori: Madia, Federica, Wei, Min, Yuan, Valerie, Hu, Jia, Gattazzo, Cristina, Pham, Phuong, Goodman, Myron F., Longo, Valter D.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2009
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Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733759/
https://ncbi.nlm.nih.gov/pubmed/19687253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200906011
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