Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways

As exome sequencing gives way to genome sequencing, the need to interpret the function of regulatory DNA becomes increasingly important. To test whether evolutionary conservation of cis-regulatory modules (CRMs) gives insight into human gene regulation, we determined transcription factor (TF) bindin...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Ballester, Benoit, Medina-Rivera, Alejandra, Schmidt, Dominic, Gonzàlez-Porta, Mar, Carlucci, Matthew, Chen, Xiaoting, Chessman, Kyle, Faure, Andre J, Funnell, Alister PW, Goncalves, Angela, Kutter, Claudia, Lukk, Margus, Menon, Suraj, McLaren, William M, Stefflova, Klara, Watt, Stephen, Weirauch, Matthew T, Crossley, Merlin, Marioni, John C, Odom, Duncan T, Flicek, Paul, Wilson, Michael D
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2014
Matèries:
Genomics and Evolutionary Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359374/
https://ncbi.nlm.nih.gov/pubmed/25279814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02626
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