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Decoupling of evolutionary changes in transcription factor binding and gene expression in mammals

To understand the evolutionary dynamics between transcription factor (TF) binding and gene expression in mammals, we compared transcriptional output and the binding intensities for three tissue-specific TFs in livers from four closely related mouse species. For each transcription factor, TF-dependen...

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Détails bibliographiques
Publié dans:Genome Res
Auteurs principaux: Wong, Emily S., Thybert, David, Schmitt, Bianca M., Stefflova, Klara, Odom, Duncan T., Flicek, Paul
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315291/
https://ncbi.nlm.nih.gov/pubmed/25394363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.177840.114
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