Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways

As exome sequencing gives way to genome sequencing, the need to interpret the function of regulatory DNA becomes increasingly important. To test whether evolutionary conservation of cis-regulatory modules (CRMs) gives insight into human gene regulation, we determined transcription factor (TF) bindin...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ballester, Benoit, Medina-Rivera, Alejandra, Schmidt, Dominic, Gonzàlez-Porta, Mar, Carlucci, Matthew, Chen, Xiaoting, Chessman, Kyle, Faure, Andre J, Funnell, Alister PW, Goncalves, Angela, Kutter, Claudia, Lukk, Margus, Menon, Suraj, McLaren, William M, Stefflova, Klara, Watt, Stephen, Weirauch, Matthew T, Crossley, Merlin, Marioni, John C, Odom, Duncan T, Flicek, Paul, Wilson, Michael D
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Genomics and Evolutionary Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359374/
https://ncbi.nlm.nih.gov/pubmed/25279814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02626
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