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Identification of human TERT elements necessary for telomerase recruitment to telomeres

Human chromosomes terminate in telomeres, repetitive DNA sequences bound by the shelterin complex. Shelterin protects chromosome ends, prevents recognition by the DNA damage machinery, and recruits telomerase. A patch of amino acids, termed the TEL-patch, on the OB-fold domain of the shelterin compo...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Schmidt, Jens C, Dalby, Andrew B, Cech, Thomas R
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359370/
https://ncbi.nlm.nih.gov/pubmed/25271372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03563
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