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Dynamics of human telomerase recruitment depend on template-telomere base pairing

The reverse transcriptase telomerase adds telomeric repeats to chromosome ends to counteract telomere shortening and thereby assures genomic stability in dividing human cells. Key parameters in telomere homeostasis are the frequency with which telomerase engages the chromosome end and the number of...

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Bibliografske podrobnosti
izdano v:Mol Biol Cell
Main Authors: Schmidt, Jens C., Zaug, Arthur J., Kufer, Regina, Cech, Thomas R.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905299/
https://ncbi.nlm.nih.gov/pubmed/29386295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-11-0637
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