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Identification of human TERT elements necessary for telomerase recruitment to telomeres

Human chromosomes terminate in telomeres, repetitive DNA sequences bound by the shelterin complex. Shelterin protects chromosome ends, prevents recognition by the DNA damage machinery, and recruits telomerase. A patch of amino acids, termed the TEL-patch, on the OB-fold domain of the shelterin compo...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Schmidt, Jens C, Dalby, Andrew B, Cech, Thomas R
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359370/
https://ncbi.nlm.nih.gov/pubmed/25271372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03563
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