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Identification of human TERT elements necessary for telomerase recruitment to telomeres
Human chromosomes terminate in telomeres, repetitive DNA sequences bound by the shelterin complex. Shelterin protects chromosome ends, prevents recognition by the DNA damage machinery, and recruits telomerase. A patch of amino acids, termed the TEL-patch, on the OB-fold domain of the shelterin compo...
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| 發表在: | eLife |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4359370/ https://ncbi.nlm.nih.gov/pubmed/25271372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03563 |
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