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Identification of human TERT elements necessary for telomerase recruitment to telomeres

Human chromosomes terminate in telomeres, repetitive DNA sequences bound by the shelterin complex. Shelterin protects chromosome ends, prevents recognition by the DNA damage machinery, and recruits telomerase. A patch of amino acids, termed the TEL-patch, on the OB-fold domain of the shelterin compo...

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Pubblicato in:eLife
Autori principali: Schmidt, Jens C, Dalby, Andrew B, Cech, Thomas R
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359370/
https://ncbi.nlm.nih.gov/pubmed/25271372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03563
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