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Lis1 regulates dynein by sterically blocking its mechanochemical cycle
Regulation of cytoplasmic dynein's motor activity is essential for diverse eukaryotic functions, including cell division, intracellular transport, and brain development. The dynein regulator Lis1 is known to keep dynein bound to microtubules; however, how this is accomplished mechanistically re...
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| Veröffentlicht in: | eLife |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4359366/ https://ncbi.nlm.nih.gov/pubmed/25380312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03372 |
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