Lis1 regulates dynein by sterically blocking its mechanochemical cycle

Regulation of cytoplasmic dynein's motor activity is essential for diverse eukaryotic functions, including cell division, intracellular transport, and brain development. The dynein regulator Lis1 is known to keep dynein bound to microtubules; however, how this is accomplished mechanistically re...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Toropova, Katerina, Zou, Sirui, Roberts, Anthony J, Redwine, William B, Goodman, Brian S, Reck-Peterson, Samara L, Leschziner, Andres E
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2014
Pynciau:
Biochemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359366/
https://ncbi.nlm.nih.gov/pubmed/25380312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03372
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