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Stimulation of hERG1 channel activity promotes a calcium-dependent degradation of cyclin E2, but not cyclin E1, in breast cancer cells

Cyclin E2 gene amplification, but not cyclin E1, has been recently defined as marker for poor prognosis in breast cancer, and appears to play a major role in proliferation and therapeutic resistance in several breast cancer cells. Our laboratory has previously reported that stimulation of the hERG1...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Perez-Neut, Mathew, Shum, Andrew, Cuevas, Bruce D., Miller, Richard, Gentile, Saverio
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359320/
https://ncbi.nlm.nih.gov/pubmed/25596745
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