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Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma

Ion channels play a major factor in maintaining cellular homeostasis but very little is known about the role of these proteins in cancer biology. In this work we have discovered that, the Kv11.3 (hERG3) a plasma-membrane potassium channel plays a critical role in the regulation of autophagy in a can...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Perez-Neut, Mathew, Haar, Lauren, Rao, Vidhya, Santha, Sreevidya, Lansu, Katherine, Rana, Basabi, Jones, Walter K., Gentile, Saverio
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008339/
https://ncbi.nlm.nih.gov/pubmed/26942884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7831
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