Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth

INTRODUCTION: Human epidermal growth factor receptor HER3 has been implicated in promoting the aggressiveness and metastatic potential of breast cancer. Upregulation of HER3 has been found to be a major mechanism underlying drug resistance to EGFR and HER2 tyrosine kinase inhibitors and to endocrine...

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Gepubliceerd in:Breast Cancer Res
Hoofdauteurs: Ren, Xiu-Rong, Wang, Jiangbo, Osada, Takuya, Mook, Robert A, Morse, Michael A, Barak, Larry S, Lyerly, Herbert Kim, Chen, Wei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358700/
https://ncbi.nlm.nih.gov/pubmed/25849870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-015-0528-9
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