Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells

INTRODUCTION: Sustained HER2 signaling at the cell surface is an oncogenic mechanism in a significant proportion of breast cancers. While clinically effective therapies targeting HER2 such as mAbs and tyrosine kinase inhibitors exist, tumors overexpressing HER2 eventually progress despite treatment....

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Main Authors:	Ren, Xiu-Rong, Wei, Junping, Lei, Gangjun, Wang, Jiangbo, Lu, Jiuyi, Xia, Wenle, Spector, Neil, Barak, Larry S, Clay, Timothy M, Osada, Takuya, Hamilton, Erika, Blackwell, Kimberly, Hobeika, Amy C, Morse, Michael A, Lyerly, H Kim, Chen, Wei
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2012
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3446352/ https://ncbi.nlm.nih.gov/pubmed/22676470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3204
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Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells

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