Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells

INTRODUCTION: Sustained HER2 signaling at the cell surface is an oncogenic mechanism in a significant proportion of breast cancers. While clinically effective therapies targeting HER2 such as mAbs and tyrosine kinase inhibitors exist, tumors overexpressing HER2 eventually progress despite treatment....

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Main Authors: Ren, Xiu-Rong, Wei, Junping, Lei, Gangjun, Wang, Jiangbo, Lu, Jiuyi, Xia, Wenle, Spector, Neil, Barak, Larry S, Clay, Timothy M, Osada, Takuya, Hamilton, Erika, Blackwell, Kimberly, Hobeika, Amy C, Morse, Michael A, Lyerly, H Kim, Chen, Wei
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446352/
https://ncbi.nlm.nih.gov/pubmed/22676470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3204
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