Autophagy Enhances Intestinal Epithelial Tight Junction Barrier Function by Targeting Claudin-2 Protein Degradation

Autophagy is an intracellular degradation pathway and is considered to be an essential cell survival mechanism. Defects in autophagy are implicated in many pathological processes, including inflammatory bowel disease. Among the innate defense mechanisms of intestinal mucosa, a defective tight juncti...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Nighot, Prashant K., Hu, Chien-An Andy, Ma, Thomas Y.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358142/
https://ncbi.nlm.nih.gov/pubmed/25616664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.597492
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