Presenilin Transmembrane Domain 8 Conserved AXXXAXXXG Motifs Are Required for the Activity of the γ-Secretase Complex

Understanding the molecular mechanisms controlling the physiological and pathological activity of γ-secretase represents a challenging task in Alzheimer disease research. The assembly and proteolytic activity of this enzyme require the correct interaction of the 19 transmembrane domains (TMDs) prese...

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發表在:J Biol Chem
Main Authors: Marinangeli, Claudia, Tasiaux, Bernadette, Opsomer, Rémi, Hage, Salim, Sodero, Alejandro O., Dewachter, Ilse, Octave, Jean Noël, Smith, Steven O., Constantinescu, Stefan N., Kienlen-Campard, Pascal
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2015
主題:
Neurobiology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358137/
https://ncbi.nlm.nih.gov/pubmed/25614624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.601286
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