Regulation of Sarcoplasmic Reticulum Ca(2+) ATPase 2 (SERCA2) Activity by Phosphodiesterase 3A (PDE3A) in Human Myocardium: PHOSPHORYLATION-DEPENDENT INTERACTION OF PDE3A1 WITH SERCA2

Cyclic nucleotide phosphodiesterase 3A (PDE3) regulates cAMP-mediated signaling in the heart, and PDE3 inhibitors augment contractility in patients with heart failure. Studies in mice showed that PDE3A, not PDE3B, is the subfamily responsible for these inotropic effects and that murine PDE3A1 associ...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Ahmad, Faiyaz, Shen, Weixing, Vandeput, Fabrice, Szabo-Fresnais, Nicolas, Krall, Judith, Degerman, Eva, Goetz, Frank, Klussmann, Enno, Movsesian, Matthew, Manganiello, Vincent
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358103/
https://ncbi.nlm.nih.gov/pubmed/25593322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.638585
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