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Regulation of Sarcoplasmic Reticulum Ca(2+) ATPase 2 (SERCA2) Activity by Phosphodiesterase 3A (PDE3A) in Human Myocardium: PHOSPHORYLATION-DEPENDENT INTERACTION OF PDE3A1 WITH SERCA2

Cyclic nucleotide phosphodiesterase 3A (PDE3) regulates cAMP-mediated signaling in the heart, and PDE3 inhibitors augment contractility in patients with heart failure. Studies in mice showed that PDE3A, not PDE3B, is the subfamily responsible for these inotropic effects and that murine PDE3A1 associ...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Biol Chem
मुख्य लेखकों: Ahmad, Faiyaz, Shen, Weixing, Vandeput, Fabrice, Szabo-Fresnais, Nicolas, Krall, Judith, Degerman, Eva, Goetz, Frank, Klussmann, Enno, Movsesian, Matthew, Manganiello, Vincent
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2015
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358103/
https://ncbi.nlm.nih.gov/pubmed/25593322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.638585
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