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Concerted and differential actions of two enzymatic domains underlie Rad5 contributions to DNA damage tolerance

Many genome maintenance factors have multiple enzymatic activities. In most cases, how their distinct activities functionally relate with each other is unclear. Here we examined the conserved budding yeast Rad5 protein that has both ubiquitin ligase and DNA helicase activities. The Rad5 ubiquitin li...

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Publicat a:Nucleic Acids Res
Autors principals: Choi, Koyi, Batke, Sabrina, Szakal, Barnabas, Lowther, Jonathan, Hao, Fanfan, Sarangi, Prabha, Branzei, Dana, Ulrich, Helle D., Zhao, Xiaolan
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357696/
https://ncbi.nlm.nih.gov/pubmed/25690888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv004
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