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Concerted and differential actions of two enzymatic domains underlie Rad5 contributions to DNA damage tolerance

Many genome maintenance factors have multiple enzymatic activities. In most cases, how their distinct activities functionally relate with each other is unclear. Here we examined the conserved budding yeast Rad5 protein that has both ubiquitin ligase and DNA helicase activities. The Rad5 ubiquitin li...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Choi, Koyi, Batke, Sabrina, Szakal, Barnabas, Lowther, Jonathan, Hao, Fanfan, Sarangi, Prabha, Branzei, Dana, Ulrich, Helle D., Zhao, Xiaolan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357696/
https://ncbi.nlm.nih.gov/pubmed/25690888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv004
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