shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance

The mechanisms underlying tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML) patients lacking explanatory BCR-ABL1 kinase domain mutations are incompletely understood. To identify mechanisms of TKI resistance that are independent of BCR-ABL1 kinase activity, we introduced a...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Khorashad, Jamshid S., Eiring, Anna M., Mason, Clinton C., Gantz, Kevin C., Bowler, Amber D., Redwine, Hannah M., Yu, Fan, Kraft, Ira L., Pomicter, Anthony D., Reynolds, Kimberly R., Iovino, Anthony J., Zabriskie, Matthew S., Heaton, William L., Tantravahi, Srinivas K., Kauffman, Michael, Shacham, Sharon, Chenchik, Alex, Bonneau, Kyle, Ullman, Katharine S., O’Hare, Thomas, Deininger, Michael W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2015
Konular:
Myeloid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357584/
https://ncbi.nlm.nih.gov/pubmed/25573989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-08-588855
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